In case of booking please read carefully all entry/visa requirements and mandatory vaccination (such as Yellow Fewer) before you book this deal. While Iberia´s tariff allows to book these open-jaw/roundtrip tickets thorought whole year 2015 you may find the cheapest flights mainly within April and May (and in some cases also between September till November 2015).
Booking samples
Spain - Accra from €251 (directly with Iberia, travel date sample 9. - 20.5.)
Barcelona - Accra - London/Brussels for £182/€256 (travel date sample 9. - 24.5.)
Spain - Accra - London for £175
Spain - Accra - Brussels for €235 (+€22 booking fee)
Brussels - Accra - London for £182
Brussels - Accra - London for €240 (+€22 booking fee)
London - Accra from £240 or directly with Iberia for £251
Brussels - Accra from €254 (+€22 booking fee)
Travel date options
Outbound flights vary by the origin airport but generally you are more flexible and should work for most of the days however it seems that to book the cheapest flights avaialble your return flight has to be either on Wednesday or Sunday.
To check your connection possibilities from your hometown we recommend to use service of Skyscanner giving you quickly a cheap solution based on various low-cost airlines.
Booking sample of cheap return flights to Africa from Europe for £175 here. In this case you would be departing from Barcelona to Accra on 9th of May. Your return flight from Ghana back to London would be on 24th of May 2015.