LATAM Airlines Group (together with their partners) offer discounted return flights from Rome to Sao Paulo. For limited travel dates you can book roundtrip flights on said route already for €340 incl. all taxes and fees and onboard meals. Checked bag available for extra fee. Some of the flights may have one layover in Frankfurt or Madrid on your way. However for similar price you can find flights with direct service in both directions so make sure you choose proper routing..
*UPDATE*.: Alitalia to match LATAM´s deal now offering greatly discounted non-stop flights from Rome to Sao Paulo from €372 including checked bag!
As mentioned LATAM AIrlines offer very limited availability at the lowest fare. Look for flights in travel period from 20th of January till 16th of May 2019. Based on latest date of your outbound flight from Italy to Brazil. Below you can find our booking as well as few travel date samples. You can compare all the cheapest flights Rome-Sao Paulo directly at website of the carrier.
Booking sample
Rome - Sao Paulo from €339 (LATAM - no checked bag in base fare)
Rome - Sao Paulo from €372 (Alitalia - including checked bag)
Travel samples
25.1. - 7.2.
27.1. - 9.2.
2. - 15.2.
9. - 23.2.
16.2. - 3.3.
2. - 17.3.
13. - 26.3.
25.3. - 5.4.
7. - 18.5.
8. - 21.5.
9. - 23.5.
14. - 27.5.
Need affordable hotel in Brazil book your accommodation via Booking.com or Hotels.com. If you have booked these cheap flights from Rome to Sao Paulo you can also compare best prices for car rental in this destination via Rentalcars.com.
Booking sample of cheap flights from Rome to Sao Paulo from €340 return here. In htis case you would depart from Italy to Brazil on 9th of May. Return from South America back to Europe (direct service) on 22nd of May 2019.
