Another great solution to destination in North America this time based on service of Virgin Atlantic. Looking for a straight way to famous "Sin City" in Nevada consider their current promotional sale on route Manchester - Las Vegas. Direct return flights are now available already for £324 (€384)! All charges and fees as well as checked luggage are included in this fare. 
This Virgin Atlantic sale is available from 29th of October 2016 till 5th of April 2017. (Blackout period 13.-24.12. The Chepest direct flights from UK (Manchester) to Las Vegas are available on week days Monday to Wednesday. (You can also return on Thursday). Other days are available for a bit higher fare. You may refer to below booking sample if interested in this solution with Virgin Atlantic..
Booking samples
Manchester - Las Vegas from £324 (direct flight)
Travel dates are the fastest to check here. I have noticed that when searching for a travel option at the website of the carrier the price is going up fairly quick after just few searches = clear your cookies in such case..You can book some afforeable accommodation in Las Vegas you may use Booking.com also consider following promo codes offered by Hotels.com, Amoma, Ebookers, Hotelopia or Venere.
Booking sample of cheap direct flights from UK (Manchester) to Las Vegas from £324 here. In this case you woule depart from Manchester to The Sin City on 8th of November. Your return flight from America back to the UK would be on 22nd of November 2016.
